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Antinociceptive, antiinflammatory and antipyretic properties of Channa striatus fillet aqueous and lipid-based extracts in rats


Citation

Zakaria, Zainul Amiruddin and Kumar, Gunjan Hanan and Mat Jais, Abdul Manan and Sulaiman, Mohd Roslan and Somchit, Muhammad Nazrul (2008) Antinociceptive, antiinflammatory and antipyretic properties of Channa striatus fillet aqueous and lipid-based extracts in rats. Methods and Findings in Experimental and Clinical Pharmacology, 30 (5). pp. 355-362. ISSN 0379-0355; ESSN: 2013-0155

Abstract

The present study was carried out to elucidate the antinociceptive, antiinflammatory and antipyretic properties of the aqueous and lipid-based extracts of Channa striatus fillet in rats. The antinociceptive activity was assessed using the formalin test, and the antiinflammatory and antipyretic activities were assessed using the carrageenan-induced paw edema and brewer's yeast-induced pyrexia tests, respectively. Both types of extracts were prepared in concentrations of 10%, 50% and 100% by serial dilution in distilled water or dimethyl sulfoxide, respectively, and were administered subcutaneously 30 min prior to each test. Except for the 10% aqueous extract which exhibits activity only in the early phase, the extracts were found to exhibit significant (P < 0. 05) activity in the early and late phases of the formalin test. Furthermore, the aqueous and lipid-based extracts were also found to show significant (P < 0. 05) antiinflammatory activity, with the former showing a greater effect at the lowest concentration used. The lipid-based, but not the aqueous, extract was found to have significant (P < 0.05) activity in the pyrexia test. In conclusion, the present study demonstrated that C. striatus extracts possess antinociceptive, antiinflammatory and antipyretic activities.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
Publisher: Prous Science
Keywords: Antiinflammatory activity; Antinociceptive activity; Antipyretic activity; Channa striatus extracts
Depositing User: Raja Norazlinda Raja Azenam
Date Deposited: 05 Dec 2014 08:36
Last Modified: 06 Jun 2016 05:35
URI: http://psasir.upm.edu.my/id/eprint/13175
Statistic Details: View Download Statistic

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