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Antinociceptive and anti-inflammatory activities of the aqueous extract of Kaempferia galanga leaves in animal models.


Citation

Sulaiman, Mohd Roslan and Zakaria, Zainul Amiruddin and Israf Ali, Daud Ahmad and Ng, F. N. and Ng, Y. C. and Baharuldin, Mohamad Taufik Hidayat (2008) Antinociceptive and anti-inflammatory activities of the aqueous extract of Kaempferia galanga leaves in animal models. Journal of Natural Medicines, 62 (2). pp. 221-227. ISSN 1340-3443; ESSN: 1861-0293

Abstract

This study was performed to determine the antinociceptive and anti-inflammatory activities of aqueous extract of Kaempferia galanga leaves using various animal models. The extract, in the doses of 30, 100, and 300 mg/kg, was prepared by soaking (1:10; w/v) the air-dried powdered leaves (40 g) in distilled water (dH2O) for 72 h and administered subcutaneously in mice/rats 30 min prior to the tests. The extract exhibited significant (P < 0.05) antinociceptive activity when assessed using the abdominal constriction, hot-plate and formalin tests, with activity observed in all tests occurring in a dose-dependent manner. Furthermore, the antinociceptive activity of K. galanga extract was significantly (P < 0.05) reversed when prechallenged with 10 mg/kg naloxone. The extract also produced a significantly (P < 0.05) dose-dependent anti-inflammatory activity when assessed using the carrageenan-induced paw-edema test. In conclusion, this study demonstrated that K. galanga leaves possessed antinociceptive and anti-inflammatory activities and thus supports the Malay's traditional uses of the plant for treatments of mouth ulcer, headache, sore throat, etc.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
DOI Number: https://doi.org/10.1007/s11418-007-0210-3
Publisher: Springer Verlag
Keywords: Anti-inflammatory activity; Antinociceptive activity; Aqueous extract; Kaempferia galanga; Opioid receptor
Depositing User: Raja Norazlinda Raja Azenam
Date Deposited: 06 Dec 2014 03:27
Last Modified: 06 Dec 2014 03:27
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1007/s11418-007-0210-3
URI: http://psasir.upm.edu.my/id/eprint/13165
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