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Anti-inflammatory and antinociceptive activities of the ethanolic extract of Pluchea indica (L) less leaf


Citation

Abd Hamid @ Abdul Razak, Roslida and A. K., Erazuliana and Ahmad, Zuraini (2008) Anti-inflammatory and antinociceptive activities of the ethanolic extract of Pluchea indica (L) less leaf. Pharmacologyonline, 2. pp. 349-360. ISSN 1827-8620

Abstract

Ethanolic extract of Pluchea indica leaf (PIL) was used to investigate its anti-inflammatory and antinociceptive activities by using carrageenan - induced oedema model and acetic acid induced writhing test. PIL exhibited significant and dose-dependent anti-inflammatory activity at a dose of 300 mg/kg when administered orally. It is also demonstrated that the i.p administration of PIL at a dose of 10, 30, 100 and 300 mg/kg produced significant inhibition of abdominal constriction induced with 0.6% (v/v) acetic acid in dose dependent manner. These results indicate that PIL exhibits significant anti-inflammatory and antinociceptive effects.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
Publisher: Società Italo-Latinoamericana di Etnomedicina
Keywords: Acetic acid induced writhing; Carrageenan-induced oedema; Pluchea indica
Depositing User: Nabilah Mustapa
Date Deposited: 26 Jan 2016 02:17
Last Modified: 31 Oct 2016 01:53
URI: http://psasir.upm.edu.my/id/eprint/13149
Statistic Details: View Download Statistic

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