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Anti-inflammatory and anti-hyperalgesic effects of Ardisia crispa Thunb. D.C


Citation

Abd Hamid @ Abdul Razak, Roslida and Kim, Kah Hwi (2008) Anti-inflammatory and anti-hyperalgesic effects of Ardisia crispa Thunb. D.C. Pharmacognosy Magazine, 4 (16). pp. 262-268. ISSN 0973-1296; ESSN: 0976-4062

Abstract

Ardisia crispa Thunb D.C (Myrsinaceae), has long been used in treating various ailments among the local villagers. The objective of this study was to investigate experimentally the possible anti-inflammatory and anti-hyperalgesic properties of Ardisia crispa. The effect of hexane fraction of ethanolic extract of root of Ardisia crispa (ACRH) was evaluated in experimental models of pain and inflammation. The root extract at 3-300 mg/kg showed significant inhibition in carrageenan-induced oedema in rats with a maximum of 93.34% at 300 mg/ kg. There was a significant (p<0.001) inhibition in carrageenan-induced hyperalgesia with ACRH 30, 100 and 300 mg/kg. The anti-inflammatory observed with the extract were comparable to that of standard. The present study indicates that the hexane fraction of Ardisia crispa (ACRH) exhibits significant anti-inflammatory and anti-hyperalgesic effects.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
Publisher: Wolters Kluwer - Medknow Publications and Media
Keywords: Anti-hyperalgesic; Anti-inflammatory; Ardisia crispa; Carrageenan-induced hyperalgesia; Carrageenan-induced oedema
Depositing User: Nabilah Mustapa
Date Deposited: 27 Jan 2016 03:03
Last Modified: 31 Oct 2016 01:50
URI: http://psasir.upm.edu.my/id/eprint/13146
Statistic Details: View Download Statistic

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