Labisia pumila (Kacip Fatimah) prevented multiple organ deteriorations in diabetic rats

Labisia pumila (LP) is traditionally used in Malaysia for women’s health. This study evaluated the protective effects of LP leaf extract on internal organs in streptozotocin (STZ)-induced diabetic rats. Thirty male rats were divided into five groups: healthy control, non-treated diabetic, diabetic treated with metformin (200 mg/kg), and diabetic treated with LP extract at 150 or 300 mg/kg. Diabetes was induced by a single intraperitoneal injection of STZ (60 mg/kg) and confirmed after 72 hours. Treatments were administered orally for 10 weeks. Serum oxidative stress, inflammatory, and epithelial biomarkers were quantified using ELISA. Untreated diabetic rats showed significantly reduced glutathione (GSH), Claudin-1, and albumin levels, along with elevated malondialdehyde (MDA), matrix metalloproteinase-13 (MMP-13), vascular endothelial growth factor (VEGF), tumor necrosis factor-α (TNF-α), and prostaglandin E2 (PGE2) compared with healthy controls. LP extract markedly attenuated diabetes-induced damage in the pancreas, liver, kidneys, heart, lungs, and spleen, and was more effective than metformin. The 150 mg/kg dose was superior at reducing oxidative stress, while the 300 mg/kg dose exerted stronger anti-inflammatory and epithelial barrier-restoring effects, indicating complementary, dose-specific actions..

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