Innovative carrier in cancer therapy: utilization of ZIF-8 as a nanocarrier for combination cancer pharmacotherapy: a review

Metal–Organic Frameworks(MOFs) have rapidly emerged as versatile nanoparticlessystem fortheir use in biomedical field, especially in drug delivery. Of the materialsin this class, zeolitic imidazolate framework ZIF-8 hasrecently captured significant interest due to itstunable structure and significant potential forsurface modification.It isthese same featureswhich allowZIF-8 to act as a suitable carrierin both single agent and combination therapy.In particular,surface chemistrywill be reiterated throughout the present article assignificant in improving the physicochemicalstability, biocompatibility and targeted drug delivery of the materials.In addition, throughwell-designed modification strategies ZIF-8 hereinwe propose to showcontrolled release profiles, improved colloidalstability, and improved therapeutic efficacy. Thisreviewwill discussrecent advances made in the surface engineering of ZIF-8 and presentsalient design principles and functionalisation techniques and their usefulnessin the area of drug-delivery applications.

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