Integrative bioinformatics analysis and whole exome sequencing reveal differentially expressed genes and single nucleotide polymorphisms in Dupuytren’s contracture

Introduction: Dupuytren's Contracture (DC) is an inherited connective tissue disorder causing abnormal thickening of the palmar fascia, leading to nodules and cords in the palm. DC is suggested to be inherited in an autosomal dominant manner with incomplete penetrance. Although many studies have been conducted to comprehend DC, to date the specific aetiology remains unclear. Thus, the objective of the present study is to identify the differentially expressed genes (DEGs) and causal variants potentially leading to the development of DC through bioinformatics analysis and whole exome sequencing (WES).

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