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Toxicity effects of caffeine in ICR mice prior to anti-malarial studys


Citation

Noriman, Ahmad Zakwan and Wan Hanafi, Wan Nurhayati and Basir, Rusliza and Agustar, Hani Kartini and Mohd Abd Razak, Mohd Ridzuan and Mohd Hassan, Wan Rozianoor (2024) Toxicity effects of caffeine in ICR mice prior to anti-malarial studys. Advances in Biological Sciences Research. pp. 3-16. ISSN 2731-7846; eISSN: 2468-5747

Abstract

Caffeine is a stimulant that increase alertness in the body. However, little is known on the toxicity effects of caffeine in ICR mice. This study aimed to identify the toxicity effects of caffeine in ICR mice for further anti-malarial investigation. Adult ICR mice were injected with caffeine (5, 10, 20 mg/kg) for four days via intraperitoneal injection (i.p.) and were monitored for 30 days. All doses exhibited no changes in body temperature, locomotor activity and urine colour when compared to control mice. Besides that, there were no signs of piloerection and lethargic whereas the mice body weight kept increasing in 30 days of monitoring. Therefore, the treatment of caffeine with 5, 10 and 20 mg/kg b.w. in ICR mice exhibited no toxicity signs and can be used for further anti-malarial study.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
DOI Number: https://doi.org/10.2991/978-94-6463-536-2_2
Publisher: Atlantis Press International BV
Keywords: Anti-malarial study; Caffeine; ICR mice; Toxicity effects.
Depositing User: Mr. Mohamad Syahrul Nizam Md Ishak
Date Deposited: 04 Nov 2025 08:37
Last Modified: 09 Jan 2026 00:37
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.2991/978-94-6463-536-2_2
URI: http://psasir.upm.edu.my/id/eprint/121500
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