In Vitro evaluation of T- cell Acute Lymphoblastic Leukemia cell line response to a combination of dual anticancer agent: SRJ23 and Hydroxyurea

Citation

Khalid, Bahariah and Karuppiah, Thilakavathy and Stanslas, Johnson and Marashdeh, Laith (2024) In Vitro evaluation of T- cell Acute Lymphoblastic Leukemia cell line response to a combination of dual anticancer agent: SRJ23 and Hydroxyurea. In: 21st Malaysian Society of Haematology Annual Scientific Meeting, 18-20 Apr. 2024, Shangri-La Hotel in Kuala Lumpur. . (Unpublished)

Abstract

T-cell acute lymphoblastic leukemia (T-ALL) is a hostile haematologic neoplasm caused by a malignant transformation of immature progenitors of T-cells. Due to the variable response to conventional chemotherapy regimens available to-date, a holistic chemotherapy combination drugs with greater precision to obtain the desired results are worth studying. We aim to evaluate the inhibitory effect of a readily available cyto-reducing agent, hydroxyurea (HU) with SRJ23, on Jurkat cell line which are an immortalised of human T lymphocyte cells to determine the efficacy in vitro.

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Additional Metadata

Item Type:	Conference or Workshop Item (Poster)
Divisions:	Faculty of Medicine and Health Science
Keywords:	SRJ23; Hydroxyurea; TALL; Jurkat cell line; Response; Apoptosis; Growth inhibitory
Depositing User:	Mr. Mohamad Syahrul Nizam Md Ishak
Date Deposited:	28 Oct 2025 00:37
Last Modified:	28 Oct 2025 00:37
URI:	http://psasir.upm.edu.my/id/eprint/121122
Statistic Details:	View Download Statistic

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