Citation
Faridnia, Farnaz
(2010)
The Binding Of Bifidobacterium Pseudocatenulatum G4 Tomutagenic/Carcinogenic Heterocyclic Aromatic Aminesin An In Vitro Study.
Masters thesis, Universiti Putra Malaysia.
Abstract
Consumption of probiotic microorganisms has been associated with decreased risk
of colon cancer and reported to have antimutagenic/anticarcinogenic properties.
Lactic acid bacteria (LAB) existing in the colon may exert an anticarcinogenic
action, but the mechanism is still poorly understood. One possible mechanism for
this effect involves physical binding of the mutagenic compounds, such as
heterocyclic amines, to the bacteria. Therefore, the purpose of this study was to
study the binding assay of mutagenic/carcinogenic heterocyclic aromatic amines
(HCAs) to Bifidobacterium pseudocatenulatum G4, a species which has not been
explored yet as a commercial probiotic, in vitro. The effect of two gram positive
bacteria: Bifidobacterium pseudocatenulatum G4 and Bifidobacterium longum
BB536 (a commercial probiotic used as a reference strain), and a gram negative
bacterium: human intestinal strain Escherichia coli ATCC 25922 at the colon environmental pH and temperature were studied.
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