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The metabolic syndrome: an overview and proposed mechanisms


Citation

Thomaz, Fernanda Santos and John, Oliver Dean and Sinha, Payel and Shafie, Siti Raihanah and Worrall, Simon (2024) The metabolic syndrome: an overview and proposed mechanisms. Obesities, 4 (3). pp. 226-255. ISSN 2673-4168; eISSN: 2673-4168

Abstract

Obesity has emerged as a major public health challenge in the 21st century, contributing to the rising prevalence of metabolic syndrome (MetS), a cluster of interrelated health risk factors. These factors include obesity or abdominal obesity, type 2 diabetes mellitus (T2DM), hypertension (HTN), and dyslipidaemia. In this review, we will explore important aspects of metabolic regulation and the dynamics of lipoprotein metabolism to see how they underlie each of these major health risks. Additionally, we will highlight the role of ferroptosis, an iron-dependent regulated cell death process, in relation to inflammatory responses and its critical contribution to the pathophysiology of MetS. These inflammatory responses include inflammasome activation, lipotoxicity, the influence of adipocytokines, and the role of adipose tissue macrophages. By exploring these interconnections, this review aims to provide insights into metabolic crosstalk, outline the pathological mechanisms occurring, and identify potential therapeutic targets for managing and preventing the progression of these health risk factors.


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Official URL or Download Paper: https://www.mdpi.com/2673-4168/4/3/20

Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
DOI Number: https://doi.org/10.3390/obesities4030020
Publisher: Multidisciplinary Digital Publishing Institute
Keywords: Obesity; Metabolic syndrome; Hypertension; Type 2 diabetes
Depositing User: Ms. Nur Faseha Mohd Kadim
Date Deposited: 03 Jul 2025 07:59
Last Modified: 03 Jul 2025 07:59
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.3390/obesities4030020
URI: http://psasir.upm.edu.my/id/eprint/118284
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