Targeting 8-oxoguanine DNA glycosylase-1 (OGG1) as a therapeutic strategy in inflammatory-related diseases

Citation

Samaila, Abdullahi and Basir, Rusliza and Gambo Lawal, Mukhtar and Abas, Razif and Abdullah, Maizaton Atmadini and Abd Majid, Roslaini and Nordin, Norshariza and Hussain, Mohd Khairi and Ab Razak, Nur Izah and Yoke Keong, Yong and Aliyu, Basiru (2024) Targeting 8-oxoguanine DNA glycosylase-1 (OGG1) as a therapeutic strategy in inflammatory-related diseases. Immunopharmacology and Immunotoxicology, 46 (5). pp. 685-694. ISSN 0892-3973; eISSN: 1532-2513

Abstract

Inflammatory diseases are influenced by oxidative stress. Oxidatively damaged 8-oxoG in DNA is linked to inflammation. The enzyme OGG1 is responsible for repairing the damaged base in the DNA which is linked to pro-inflammatory signaling and severe inflammation. This study aims to explore the potential of targeting OGG1 as a therapeutic strategy in inflammatory disease conditions.

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Official URL or Download Paper: https://www.tandfonline.com/doi/full/10.1080/08923...

Additional Metadata

Item Type:	Article
Divisions:	Faculty of Medicine and Health Science
DOI Number:	https://doi.org/10.1080/08923973.2024.2391471
Publisher:	Taylor & Francis
Keywords:	OGG1; Therapeutic target; Inflammation; Inflammatory diseases; OGG1-inhibitors
Depositing User:	Ms. Zaimah Saiful Yazan
Date Deposited:	13 Jun 2025 07:29
Last Modified:	13 Jun 2025 07:29
Altmetrics:	http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1080/08923973.2024.2391471
URI:	http://psasir.upm.edu.my/id/eprint/117856
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