Citation
Albaayit, Shaymaa Fadhel Abbas and Maharjan, Rukesh and Abdullah, Rasedee and Mohd Noor, Mohd Hezmee and Ullah, Saeed and Al-Azzawi, Sura and Al-Khazraji, Husham Hussein Jasim
(2025)
Antileishmanial, insecticidal, anti-leukemic, phytotoxicity and anti-pancreatic lipase effects of ethanolic extracts of Moringa peregrina Seed.
Boletin Latinoamericano Y Del Caribe De Plantas Medicinales Y Aromáticas, 24 (2).
pp. 225-235.
ISSN 0717-7917
Abstract
In this study, the ethanolic extracts of Moringa peregrina seeds (MPSE) were evaluated for their antiparasitic, insecticidal, herbicidal, anti-leukemic, and anti-pancreatic lipase activities. The MPSE showed moderate antileishmanial activity against Leishmania major with an IC50 of 71.7 ± 0.46 μg/mL, compared to 10 ± 0.05 μg/mL and 4 ± 0.05 μg/mL for pentamidine and amphotericin B, respectively. The extract demonstrated moderate insecticidal activity with 41% mortality in Rhyzopertha dominica and 15.7% in Tribolium castaneum. MPSE exhibited potent herbicidal activity against Lemna minor at 1000 µg/mL. Additionally, MPSE inhibited the proliferation of leukemia K562 cells with an IC50 of 25 μg/mL and porcine pancreatic lipase with an IC50 of 83.7 ± 0.57 μg/mL. These findings suggest that MPSE may be beneficial as an antiparasitic, insecticidal, herbicidal, anti-leukemic, and anti-pancreatic lipase agent.
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