Xanthine oxidase inhibitory activity by flavonoids from Chrysanthemum morifolium: in vitro and in silico insights

Citation

Tey, Zi Tong and Loh, Khye Er and Tan, Siow-Ping and Yuan, Chongjun and Tejo, Bimo Ario and Ismail, Intan Safinar and Nafiah, Mohd Azlan (2024) Xanthine oxidase inhibitory activity by flavonoids from Chrysanthemum morifolium: in vitro and in silico insights. Phytochemistry Letters, 64. pp. 68-78. ISSN 1874-3900

Abstract

2-(3’,4’-dihydroxyphenyl)-3,6,7,8-tetramethoxy-4H-chromen-4-one (3), a new flavonoid was isolated from the ethyl acetate fraction of Chrysanthemum morifolium Ramat. dried flowers, while 4′,5-dihydroxy-3,3′,7,8-tetramethoxy-flavone (1) and casticine (5) were isolated from this plant for the first time, as well as two known flavonoids, eriodictyol-7-O-glucoside (2) and luteolin (4). Their structures were investigated over a broad spatial scale using chromatographic and spectroscopic techniques (NMR, FTIR, UV and HR-ESI-MS). Compound 4 showed the highest XO inhibition and the most favorable interaction with XO in molecular docking analysis. Compound 2, 3 and 4 demonstrated stable interactions with catalytically important residues in xanthine oxidase via molecular dynamic analysis.

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Additional Metadata

Item Type:	Article
Divisions:	Faculty of Science
DOI Number:	https://doi.org/10.1016/j.phytol.2024.10.002
Publisher:	Elsevier
Keywords:	Chrysanthemum morifolium; Flavonoids; Molecular docking; Molecular dynamics; Xanthine oxidase inhibitors
Depositing User:	Ms. Zaimah Saiful Yazan
Date Deposited:	09 Jul 2025 08:43
Last Modified:	09 Jul 2025 08:43
Altmetrics:	http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1016/j.phytol.2024.10.002
URI:	http://psasir.upm.edu.my/id/eprint/117569
Statistic Details:	View Download Statistic

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