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MicroRNAs and their role in breast cancer metabolism (review)


Citation

Lee, Wen Xuan and Yeo, Bann Siang and Mahmud, Rozi and Tan, Geok Chin and Abdul Wahid, Mohamed Ibrahim and Cheah, Yoke Kqueen (2024) MicroRNAs and their role in breast cancer metabolism (review). International Journal of Oncology, 66. art. no. 7. pp. 1-20. ISSN 1019-6439; eISSN: 1791-2423

Abstract

Breast cancer (BC) continues to be the leading cause of cancer-related mortality among women, placing a substantial disease burden on the global female population. MicroRNAs (miRNAs) are members of a large class of non-coding RNAs capable of regulating gene expression at the post-transcriptional level. With cases of early-onset BC on the rise, miRNAs are promising biomarkers and therapeutic targets for early BC detection and treatment. Dysregulated miRNA expression is known to be closely linked to BC development and metastasis in cancer cells via metabolic reprogramming. Normal cellular metabolism is tightly regulated by various complex signaling pathways. Therefore, dysregulation of metabolism due to metabolic reprogramming is considered a hallmark of cancer. The present review delves into the crucial roles that miRNAs serve in disordered cellular metabolism of BC by targeting gene transcripts, key metabolic enzymes and transporter proteins responsible for regulating major cellular metabolism pathways. The future outlook and clinical implications of miRNAs as potential diagnostic, prognostic and therapeutic markers in BC metabolism are also discussed.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
DOI Number: https://doi.org/10.3892/ijo.2024.5713
Publisher: Spandidos Publications
Keywords: Amino acid; Breast cancer; Glucose; Lipid; MicroRNAs; Metabolism; Metabolic dysregulation
Depositing User: Ms. Nur Faseha Mohd Kadim
Date Deposited: 30 Apr 2025 05:07
Last Modified: 30 Apr 2025 05:07
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.3892/ijo.2024.5713
URI: http://psasir.upm.edu.my/id/eprint/117191
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