Citation
Abstract
Introduction: Vascular dementia (VaD), a neurocognitive impairment directly related to vascular injury, is the second most common cause of age-related dementia. Although numerous studies have investigated candidate genetic polymorphisms associated with VaD in Asia, the genetics of VaD remains unclear. Methods: This review provides an updated meta-analysis of genetic polymorphisms associated with VaD in Asians, using the PRISMA guidelines. Published literature up to May 2021 was extracted from the PubMed, Scopus, Ovid, and EBSCOhost databases. Meta-analysis was conducted using the Open Meta analyst, Review Manager, and MedCalc® Statistical Software. Trial sequential analysis (TSA) was performed using TSA viewer software. Results: A total of 46 eligible studies, comprising 23 genes and 35 single nucleotide polymorphisms, were retrieved. The meta-analysis was conducted on the following genetic polymorphisms, APOE ε2/3/4, MTHFR rs1801131, ACE rs4340 (I/D) gene polymorphism, and a PSEN1 intron 8 variant. The pooled odds ratio (ORs) revealed a significant increase in the risk of VaD in the apolipoprotein E (APOE) ε4 allelic model (OR, 1.79, p < 0.001), and the methylenetetrahydrofolate reductase (MTHFR) rs1801133 polymorphism T allele in the allelic model (OR, 1.23, p = 0.013). Conclusion: Our findings provide evidence that genetic polymorphisms of the APOE ε4 allele and MTHFR rs1801133 T allele increase the risk of developing VaD in Asians. However, future large-scale investigations examining particularly on South-Eastern and West-Asian populations are highly recommended.
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Additional Metadata
Item Type: | Article |
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Divisions: | Faculty of Medicine and Health Science Malaysian Research Institute on Ageing |
DOI Number: | https://doi.org/10.1159/000538864 |
Publisher: | Karger Publishers |
Keywords: | Asians; Genetic polymorphism; Methylenetetrahydrofolate; Single nucleotide polymorphisms; Vascular dementia |
Depositing User: | Ms. Nur Faseha Mohd Kadim |
Date Deposited: | 28 Mar 2025 03:56 |
Last Modified: | 28 Mar 2025 03:56 |
Altmetrics: | http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1159/000538864 |
URI: | http://psasir.upm.edu.my/id/eprint/116396 |
Statistic Details: | View Download Statistic |
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