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Genetic susceptibility variants of vascular dementia among Asians: a systematic review and meta-analysis


Citation

Vasudevan, R. and Nur Afiqah, M. and Mohd Nazil, S. and Wan Aliaa, W.S. and Liyana Najwa, I.M. and Mohd Hazmi, M. and Siew Mooi, C. and Abdul Hanif Khan, Y.K. and Hamidon, B. and Pannerselvam, P. and Suganthi, V. and Narenkumar, J. (2024) Genetic susceptibility variants of vascular dementia among Asians: a systematic review and meta-analysis. Dementia and Geriatric Cognitive Disorders, 53 (4). pp. 200-216. ISSN 1420-8008; eISSN: 1421-9824

Abstract

Introduction: Vascular dementia (VaD), a neurocognitive impairment directly related to vascular injury, is the second most common cause of age-related dementia. Although numerous studies have investigated candidate genetic polymorphisms associated with VaD in Asia, the genetics of VaD remains unclear. Methods: This review provides an updated meta-analysis of genetic polymorphisms associated with VaD in Asians, using the PRISMA guidelines. Published literature up to May 2021 was extracted from the PubMed, Scopus, Ovid, and EBSCOhost databases. Meta-analysis was conducted using the Open Meta analyst, Review Manager, and MedCalc® Statistical Software. Trial sequential analysis (TSA) was performed using TSA viewer software. Results: A total of 46 eligible studies, comprising 23 genes and 35 single nucleotide polymorphisms, were retrieved. The meta-analysis was conducted on the following genetic polymorphisms, APOE ε2/3/4, MTHFR rs1801131, ACE rs4340 (I/D) gene polymorphism, and a PSEN1 intron 8 variant. The pooled odds ratio (ORs) revealed a significant increase in the risk of VaD in the apolipoprotein E (APOE) ε4 allelic model (OR, 1.79, p < 0.001), and the methylenetetrahydrofolate reductase (MTHFR) rs1801133 polymorphism T allele in the allelic model (OR, 1.23, p = 0.013). Conclusion: Our findings provide evidence that genetic polymorphisms of the APOE ε4 allele and MTHFR rs1801133 T allele increase the risk of developing VaD in Asians. However, future large-scale investigations examining particularly on South-Eastern and West-Asian populations are highly recommended.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
Malaysian Research Institute on Ageing
DOI Number: https://doi.org/10.1159/000538864
Publisher: Karger Publishers
Keywords: Asians; Genetic polymorphism; Methylenetetrahydrofolate; Single nucleotide polymorphisms; Vascular dementia
Depositing User: Ms. Nur Faseha Mohd Kadim
Date Deposited: 28 Mar 2025 03:56
Last Modified: 28 Mar 2025 03:56
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1159/000538864
URI: http://psasir.upm.edu.my/id/eprint/116396
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