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Resistance of Pseudomonas pseudomallei to normal human serum bactericidal action


Citation

Ismail, Ghazally and Razak, Nyonya and Mohamed, Rahmah and Omar, Othman and Embi, Noor (1988) Resistance of Pseudomonas pseudomallei to normal human serum bactericidal action. Microbiology and Immunology, 32 (7). pp. 645-652. ISSN 0385-5600; eISSN: 1348-0421

Abstract

The effect of human normal serum (HNS) on Pseudomonas pseudomallei was determined. It is apparent from our data that the organism is resistant to the normal serum bactericidal mechanism. Ancillary experiments to confirm this serum-resistant property of P. pseudomallei were done by examining the effects of growth phase conditions of the bacteria (i.e., logarithmic and stationary phases) and different buffered systems used as diluent in our bactericidal assay. Results obtained showed similar degree of resistance to serum bactericidal killing by 5 strains of the organisms tested. The possible survival advantage of serum-resistant property to P. pseudomallei as bacterial pathogens known to invade the blood stream is discussed.


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Additional Metadata

Item Type: Article
Divisions: Universiti Pertanian Malaysia
DOI Number: https://doi.org/10.1111/j.1348-0421.1988.tb01426.x
Publisher: Wiley
Keywords: Pseudomonas pseudomallei; Serum resistance; Bactericidal activity; Human serum; Bacterial pathogens; Bloodstream invasion; Growth phase; Buffered systems
Depositing User: Ms. Zaimah Saiful Yazan
Date Deposited: 10 Mar 2025 07:51
Last Modified: 10 Mar 2025 07:51
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1111/j.1348-0421.1988.tb01426.x
URI: http://psasir.upm.edu.my/id/eprint/115697
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