Hypoglycaemic effect of Stigmast-4-en-3-one, from Parkia speciosa empty pods

Citation

Jamaluddin, Fathaiya and Mohamed, Suhaila and Lajis, Md.Nordin (1995) Hypoglycaemic effect of Stigmast-4-en-3-one, from Parkia speciosa empty pods. Food Chemistry, 54 (1). pp. 9-13. ISSN 0308-8146; eISSN: 0308-8146

Abstract

Oral administration of the chloroform extracts of Parkia speciosa (petai papan) empty pods to alloxan-induced diabetic rats produced a significant reduction in blood glucose levels. A hypoglycaemic assay guided extraction, isolation and structure elucidation gave stigmast-4-en-3-one. Stigmast-4-en-3-one produced 84% activity at 100 mg kg-1 body weight (BW) compared to 111% activity of glibenclamide at 5 mg kg-1 BW dosages. The minimum effective dose which produced statistically significant hypoglycaemic effect was 50 mg pericarp kg-1 BW. Hypoglycaemic effect was not observed in healthy rats. Stigmast-4-en-3-one is therefore identified as a new oral hypoglycaemic agent occurring naturally in food.

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Additional Metadata

Item Type:	Article
Divisions:	Faculty of Food Science and Biotechnology Universiti Pertanian Malaysia
DOI Number:	https://doi.org/10.1016/0308-8146(95)92656-5
Publisher:	Elsevier
Keywords:	Hypoglycemic effect; Stigmast-4-en-3-one; Parkia speciosa; Petai papan; Alloxan-induced diabetes
Depositing User:	Ms. Zaimah Saiful Yazan
Date Deposited:	08 Jul 2025 04:40
Last Modified:	08 Jul 2025 04:40
Altmetrics:	http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1016/0308-8146(95)92656-5
URI:	http://psasir.upm.edu.my/id/eprint/115586
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