Aspergilloma in a young patient with autosomal-dominant hyper-IgE syndrome

Citation

Ismail, Intan Hakimah and Zainal Abidin, Mohd Azri and Mohamed Nashrudin, Khairoon Nisa (2024) Aspergilloma in a young patient with autosomal-dominant hyper-IgE syndrome. In: Asia Pacific Association of Allergy, Asthma, and Clinical Immunology (APAAACI) Congress 2024, 13-15 Dec. 2024, Kuala Lumpur, Malaysia. .

Abstract

Signal transducer and activator of transcription 3 (STAT3) deficiency is the primary cause of autosomal dominant hyper IgE syndrome (AD-HIES), also known as Job syndrome. Approximately 90% of affected individuals experience bacterial pneumonia, with about 67% developing pulmonary complications such as bronchiectasis or pneumatoceles. Moreover, STAT3 deficiency significantly predisposes patients to fungal infections, particularly aspergillosis. Aspergilloma, often referred to as a mycetoma or fungal ball, is the most frequent pulmonary manifestation of Aspergillus species, typically forming within preexisting lung cavities. Diagnosis relies on a combination of radiographic findings and serological or microbiological evidence of Aspergillus involvement.

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Additional Metadata

Item Type:	Conference or Workshop Item (Poster)
Divisions:	Faculty of Medicine and Health Science
Publisher:	Asia Pacific Association of Allergy, Asthma, and Clinical Immunology
Keywords:	Hyper-IgE syndrome; Aspergilloma; Autosomal-dominantHyper-IgEsyndrome (AD-HIES); Job syndrome; STAT3 deficiency; Pulmonary infections; Fungal infections; Aspergillus; Bronchiectasis; Pneumatoceles; Mycetoma; Diagnosis; Radiographic findings; Serological evidence; Microbiological evidence
Depositing User:	Mr. Mohamad Syahrul Nizam Md Ishak
Date Deposited:	03 Mar 2025 05:11
Last Modified:	03 Mar 2025 05:11
URI:	http://psasir.upm.edu.my/id/eprint/115329
Statistic Details:	View Download Statistic

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