Glutathione S-transferase and gamma-glutamyl transpeptidase activities in cultured rat hepatocytes treated with tocotrienol and tocopherol

Citation

Ong, F.B. and Wan Ngah, W.Z. and Shamaan, N.A. and Md. Top, A.G. and Marzuki, A. and Khalid, A.K. (1993) Glutathione S-transferase and gamma-glutamyl transpeptidase activities in cultured rat hepatocytes treated with tocotrienol and tocopherol. Comparative Biochemistry and Physiology. Part C: Comparative, 106 (1). pp. 237-240. ISSN 0742-8413; eISSN: 0742-8413

Abstract

1. The effect of tocotrienol and tocopherol on glutathione S-transferase (GST) and gammaglutamyl transpeptidase (GGT) activities in cultured rat hepatocytes were investigated. 2. Tocotrienol and tocopherol significantly decreased GGT activities at 5 days in culture but tocotrienol also significantly decreased GGT activities at 1-2 days. 3. Tocotrienol and tocopherol treatment significantly decreased GST activities at 3 days compared to the control but tocotrienol also decreased GST activities at 1-3 days. 4. Tocotrienol showed a more pronounced effect at a dosage of greater than 50 μM tocotrienol at 1-3 days in culture compared to the control. © 1993.

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Additional Metadata

Item Type:	Article
Divisions:	Faculty of Biotechnology and Biomolecular Sciences
DOI Number:	https://doi.org/10.1016/0742-8413(93)90277-R
Keywords:	gamma-Glutamyl transpeptidase; Glutathione S-transferase; Hepatocyte; Tocopherol; Tocotrienol
Depositing User:	Ms. Azian Edawati Zakaria
Date Deposited:	18 Feb 2025 07:00
Last Modified:	18 Feb 2025 07:00
Altmetrics:	http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1016/0742-8413(93)90277-R
URI:	http://psasir.upm.edu.my/id/eprint/115052
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