Citation
Noor, Hamdan and Ashcroft, Stephen J. H.
(1998)
Insulinotropic activity of Tinospora crispa extract: effect on β-cell Ca2+ handling.
Phytotherapy Research, 12 (2).
pp. 98-102.
ISSN 0951-418X; eISSN:1099-1573
Abstract
The mechanism of insulinotropic action of Tinospora crispa was investigated in vitro using an insulin-secreting clonal β-cell line, HIT-T15. The aqueous extract sensitizes the β-cell to extracellular Ca2+ and promotes intracellular Ca2+ accumulation which in turn causes increased insulin release. The increase in cytosolic Ca2+ concentration is due to stimulation of Ca2+ uptake from the extracellular medium and inhibition of Ca2+ efflux from the cytosol. That the mechanism of insulinotropic action of T. crispa is physiological suggests that the insulin secretagogue/s present in the extract could indeed be a potential source of a specific oral hypoglycaemic agent for the treatment of non-insulin-dependent diabetes mellitus.
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Additional Metadata
| Item Type: | Article |
|---|---|
| Divisions: | Faculty of Science |
| DOI Number: | https://doi.org/10.1002/(SICI)1099-1573(199803)12:2<98::AID-PTR195>3.0.CO;2-F |
| Publisher: | Wiley |
| Keywords: | β-cell; Ca<sup>2+</sup>; Diabetes mellitus; Insulin secretion; Insulinotropic; Tinospora crispia |
| Depositing User: | Ms. Nuraida Ibrahim |
| Date Deposited: | 18 Feb 2025 03:00 |
| Last Modified: | 18 Feb 2025 03:00 |
| Altmetrics: | http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1002/(SICI)1099-1573(199803)12:2<98::AID-PTR195>3.0.CO;2-F |
| URI: | http://psasir.upm.edu.my/id/eprint/115037 |
| Statistic Details: | View Download Statistic |
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