Effect of tocotrienol on the activities of cytosolic glutathione-dependent enzymes in rats treated with 2-acetylaminofluorene

Citation

Shamaan, Nor Aripin and Wan Ngah, Wan Zurinah and Ibrahim, Rusli and Jarien, Zanariah (1993) Effect of tocotrienol on the activities of cytosolic glutathione-dependent enzymes in rats treated with 2-acetylaminofluorene. Biochemical Pharmacology, 45 (7). pp. 1517-1519. ISSN 0006-2952; eISSN: 0006-2952

Abstract

The effect of tocotrienol on the activities of glutathione S-transferases (GSTs), glutathione reductase (GR) and glutathione peroxidase (GPx) in rats given 2-acetylaminofluorene (AAF) was investigated over a 20 week period. Liver and kidney GST and liver GR activities were significantly increased after AAF administration. Kidney GPx activities were significantly affected; activity assayed with cumene hydroperoxide (cu-OOH) was increased but activity assayed with H2O2 was reduced. Supplementation of the diet with tocotrienol in the AAF-treated rats reduced the increase in enzyme activities. Tocotrienol on its own had no effect on the enzyme activities. © 1993.

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Additional Metadata

Item Type:	Article
Divisions:	Faculty of Biotechnology and Biomolecular Sciences
DOI Number:	https://doi.org/10.1016/0006-2952(93)90052-X
Keywords:	2-acetylaminofluorene; Cytosolic glutathione-dependent enzymes; Glutathione peroxidase; Glutathione reductase; Glutathione S-transferases; Liver; Rats; Tocotrienol
Depositing User:	Ms. Azian Edawati Zakaria
Date Deposited:	03 Feb 2025 06:31
Last Modified:	03 Feb 2025 06:31
Altmetrics:	http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1016/0006-2952(93)90052-X
URI:	http://psasir.upm.edu.my/id/eprint/114818
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