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Frequency-dependent dielectric spectroscopic analysis on phytochemical and antioxidant activities in Radix Glycyrrhizae extract


Citation

Hong Liang, Ong and Ee Meng, Cheng and Mohamad, Che Wan Sharifah Robiah and Mohd Nasir, Nashrul Fazli and Xiao Jian, Tan and Chong You, Beh and Ziezie Mohd Tarmizi, Emma and Kim Yee, Lee and Kok Yeow, You and Shing Fhan, Khor and Kim Fey, Leu and Kian Keong, Te and Mohd Roslan, Mohd Riza and Baharuddin, Siti Aishah (2024) Frequency-dependent dielectric spectroscopic analysis on phytochemical and antioxidant activities in Radix Glycyrrhizae extract. Heliyon, 10 (17). art. no. e37077. pp. 1-10. ISSN 2405-8440; eISSN: 2405-8440

Abstract

Radix Glycyrrhizae, the dried roots of the Glycyrrhiza glabra plant, is a popular Chinese herbal medicine known for its various health benefits. It is particularly effective in relieving respiratory problems like coughs, sore throats, bronchitis, and asthma. However, there is limited research on the electrical properties of Radix Glycyrrhizae, likely due to its complex composition of phytochemical and antioxidant activities. This research aims to investigate the potential of these active biological compounds and understand their electrochemical properties. In this study, High-Performance Liquid Chromatography (HPLC) analysis revealed that Radix Glycyrrhizae decoction contains significant amounts of flavonoids and saponins, compounds known for their health benefits and therapeutic effects. Further analysis using Fourier Transform Infrared Spectroscopy (FTIR) identified several functional groups, including phenols, alcohols, alkynes, alkenes, ethers, and glycosides, which contribute to the plant's medicinal potential and affect the impedance and dielectric properties of the extract. The antioxidant activity of Radix Glycyrrhizae decoction was also evaluated using DPPH assays, showing similar radical scavenging activity to gallic acid. Dielectric and impedance measurement of Radix Glycyrrhizae extract were performed using an Agilent vector network analyzer and a Hioki impedance analyzer. The dielectric constant measured was consistent across both analyzers. However, the loss factor showed different trends: the vector network analyzer indicated a decrease in the loss factor with increasing frequency in the range of 5 MHz–20 GHz, while the impedance analyzer showed the opposite trend in the frequency range of 4 Hz–5 MHz.


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Additional Metadata

Item Type: Article
Divisions: Centre of Foundation Studies for Agricultural Science
DOI Number: https://doi.org/10.1016/j.heliyon.2024.e37077
Publisher: Elsevier
Keywords: Antioxidant; Dielectric; Phytochemical; Radix Glycyrrhizae
Depositing User: Ms. Che Wa Zakaria
Date Deposited: 17 Jan 2025 07:41
Last Modified: 17 Jan 2025 07:41
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1016/j.heliyon.2024.e37077
URI: http://psasir.upm.edu.my/id/eprint/114546
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