Citation
Tamil Segaran, Raaginie and Ng, Chean Hui and Mohd Aluwi, Mohd Fadhlizil Fasihi and Lam, Kok Wai and Shaari, Khozirah and Md Pisar, Mazura
(2024)
An eco-friendly and new facile method for synthesis of prenylated or geranylated acylphloroglucinol-based xanthenones.
Results in Chemistry, 9.
art. no. 101627.
pp. 1-5.
ISSN 2211-7156; eISSN: 2211-7156
Abstract
The synthesis of prenylated or geranylated acylphloroglucinol-based xanthenones with 15.1–36.9% yield was achieved via aldol condensation of 2,4,6-trihydroxy-3-prenylacetophenone (tHPA) or 2,4,6-trihydroxy-3-geranylacetophenone (tHGA) and 2-hydroxybenzaldehyde derivatives in the presence of lithium bis(trimethylsilyl)amide (LiHMDS) as deprotonating agent. This study is one of the first to report on the synthesis of xanthenones using strong non-nucleophilic base catalyst, and the described synthesis not only achieved a compound with a natural product skeleton but also formed in a simple and environmentally friendly specificity.
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Additional Metadata
Item Type: | Article |
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Divisions: | Institute of Bioscience |
DOI Number: | https://doi.org/10.1016/j.rechem.2024.101627 |
Publisher: | Elsevier |
Keywords: | Acylphloroglucinol-based xanthenone; Aldol condensation; Eco-friendly; LiHMDS base catalyst; Natural product skeleton |
Depositing User: | Mr. Mohamad Syahrul Nizam Md Ishak |
Date Deposited: | 25 Nov 2024 06:20 |
Last Modified: | 25 Nov 2024 06:20 |
Altmetrics: | http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1016/j.rechem.2024.101627 |
URI: | http://psasir.upm.edu.my/id/eprint/113457 |
Statistic Details: | View Download Statistic |
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