Citation
Chowdhury, S.M.Z.H. and Omar, A.R. and Aini, I. and Hair-Bejo, M. and Jamaluddin, A.A. and Md-Zain, B.M. and Kono, Y.
(2003)
Pathogenicity, sequence and phylogenetic analysis of Malaysian Chicken anaemia virus obtained after low and high passages in MSB-1 cells.
Archives of Virology, 148 (12).
pp. 2437-2448.
ISSN 0304-8608; eISSN: 1432-8798
Abstract
Specific-pathogen-free (SPF) chickens inoculated with low passage Chicken anaemia virus (CAV), SMSC-1 and 3-1 isolates produced lesions suggestive of CAV infection. Repeated passages of the isolates in cell culture until passage 60 (P60) and passage 123 produced viruses that showed a significantly reduced level of pathogenicity in SPF chickens compared to the low passage isolates. Sequence comparison indicated that nucleotide changes in only the coding region of the P60 passage isolates were thought to contribute to virus attenuation. Phylogenetic analysis indicated that SMSC-1 and 3-1 were highly divergent, but their P60 passage derivatives shared significant homology to a Japanese isolate A2.
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Additional Metadata
| Item Type: | Article |
|---|---|
| Divisions: | Faculty of Veterinary Medicine |
| DOI Number: | https://doi.org/10.1007/s00705-003-0189-3 |
| Publisher: | Springer |
| Keywords: | Pathogenicity; Chicken anaemia virus; Sequence; Phylogenetic analysis |
| Depositing User: | Ms. Zaimah Saiful Yazan |
| Date Deposited: | 13 Jan 2025 02:41 |
| Last Modified: | 13 Jan 2025 02:41 |
| Altmetrics: | http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1007/s00705-003-0189-3 |
| URI: | http://psasir.upm.edu.my/id/eprint/112956 |
| Statistic Details: | View Download Statistic |
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