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Sciadonic acid attenuates high-fat diet-induced bone metabolism disorders in mice


Citation

Yao, Shiwei and Lu, Hongling and Zhou, Tianhuan and Jiang, Qihong and Jiang, Chenkai and Hu, Wenjun and Li, Mingqian and Tan, Chin Ping and Feng, Yongcai and Du, Qun and Shen, Guoxin and Xiang, Xingwei and Chen, Lin (2024) Sciadonic acid attenuates high-fat diet-induced bone metabolism disorders in mice. Food and Function, 15 (8). pp. 4490-4502. ISSN 2042-6496; eISSN: 2042-650X

Abstract

High-fat diet (HFD) has been associated with certain negative bone-related outcomes, such as bone metabolism disruption and bone loss. Sciadonic acid (SC), one of the main nutritional and functional components of Torreya grandis seed oil, is a unique Δ5-unsaturated-polymethylene-interrupted fatty acid (Δ5-UPIFA) that has been claimed to counteract such disorders owing to some of its physiological effects. However, the role of SC in ameliorating bone metabolism disorders due to HFD remains unclear. In the present investigation, we observed that SC modulates the OPG/RANKL/RANK signaling pathway by modifying the lipid metabolic state and decreasing inflammation in mice. In turn, it could balance bone resorption and formation as well as calcium and phosphorus levels, enhance bone strength and bone mineral density (BMD), and improve its microstructure. In addition, SC could inhibit fat vacuoles in bone, reverse the phenomenon of reduced numbers and poor continuity of bone trabeculae, and promote orderly arrangement of collagen fibers and cartilage repair. This study provides some theoretical basis for SC as a dietary intervention agent to enhance bone nutrition. © 2024 The Royal Society of Chemistry.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Food Science and Technology
DOI Number: https://doi.org/10.1039/d3fo04527g
Publisher: Royal Society of Chemistry
Keywords: Bone disorders; Bone metabolism; High-fat diet; Inflammation; Sciadonic acid
Depositing User: Ms. Azian Edawati Zakaria
Date Deposited: 06 Nov 2024 04:02
Last Modified: 06 Nov 2024 04:02
URI: http://psasir.upm.edu.my/id/eprint/112845
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