UPM Institutional Repository

Antifungal garcinia acid esters from the fruits of garcinia atroviridis


Citation

Mackeen, Mukram M. and Ali, Abdul Manaf and Lajis, Nordin and Kawazu, Kazuyoshi and Kikuzaki, Hiroe and Nakatani, Nobuji (2002) Antifungal garcinia acid esters from the fruits of garcinia atroviridis. Zeitschrift für Naturforschung C, 57 (3-4). pp. 291-295. ISSN 0939-5075; eISSN: 1865-7125

Abstract

Two new garcinia acid derivatives, 2-(butoxycarbonylmethyl)-3-butoxycarbonyl-2-hydroxy3-propanolide and 1′,1″-dibutyl methyl hydroxycitrate, were isolated from the fruits of Garcinia atroviridis guided by TLC bioautography against the fungus Cladosporium herbarum. The structures of these compounds were established by spectral analysis. The former compound represents a unique β-lactone structure and the latter compound is most likely an artefact of garcinia acid (= hydroxycitric acid). Both compounds showed selective antifungal activity comparable to that of cycloheximide (MID: 0.5 μg/spot) only against C. herbarum at the MIDs of 0.4 and 0.8 μg/spot but were inactive against bacteria (Bacillus subtilis, methicillin-resistant Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli), other fungi (Alternaria sp., Fusarium moniliforme and Aspergillus ochraceous) including the yeast Candida albicans.


Download File

[img] Text
112496.pdf - Published Version
Restricted to Repository staff only
Download (92kB)

Additional Metadata

Item Type: Article
Divisions: Faculty of Food Science and Biotechnology
Institute of Bioscience
DOI Number: https://doi.org/10.1515/znc-2002-3-416
Publisher: De Gruyter
Keywords: Fruits; Garcinia atroviridis; β-Lactone
Depositing User: Ms. Zaimah Saiful Yazan
Date Deposited: 06 Mar 2025 07:16
Last Modified: 06 Mar 2025 07:16
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1515/znc-2002-3-416
URI: http://psasir.upm.edu.my/id/eprint/112496
Statistic Details: View Download Statistic

Actions (login required)

View Item View Item