Citation
Mohd Taib, Nor Azizah
(2000)
Vibriosis Vaccine Development: Pathogenesis, Immunological And Molecular Characterization Of Vibrio Alginolyticus.
Masters thesis, Universiti Putra Malaysia.
Abstract
The aim of the research is to develop an effective vaccine against vibriosis.
Vibriosis is a bacterial disease caused by Vibrio spp due to the intensive
production activity of brackishwater ponds and cage-cultured fish. The
pathogenicity study of V alginolyticus was performed by challenging the juvenile
seabass (10±0.75 g) with 5 different isolates of V alginolyticus at different cell
concentrations. All the isolates caused mortality to fish at a concentration as low
as 0.2 optical density (6.28 X 103 CFU/ml). Ultrastructure changes observed by
scanning and transmission electron microscopy, revealed the presence of
V .alginolyticus in the gills, liver, muscle, spleen and kidney of infected fish. In
addition, the V .alginolyticus cells were observed in the spleen. These
pathological changes showed that V alginolyticus was responsible for the death of
the infected seabass.
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