Citation
Moon, Nian Lim and Qi, Hao Looi and Koh, Benson and Che’ Amat, Azlan and Muhammad, Numan and Khairuddin, Nurul Hayah
(2023)
In vivo temporal penetration of mesenchymal stem cell-derived exosome eye drops across ocular tissue.
Malaysian Journal of Medicine and Health Sciences, 19 (suppl.8).
pp. 25-26.
ISSN 2636-9346
Abstract
This study explores the potential application of extracellular vesicles (EVs) or exosomes derived from human mesenchymal stem cells (MSCs) in ophthalmology. Exosomes were isolated from MSCs’ culture supernatant, and applied as eye drops to rabbits’ eyes. Samples of aqueous (AH) and vitreous humour (VH) were collected at different time points for exosomes marker analysis. Our results showed that CD63 was detected in all AH and VH samples. Whereas, for CD9 and CD81, despite minimally expressed in control samples, showed varying expression in VH samples at different time points, indicating penetration and retention of exosomes in the eyes’ structure.
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Official URL or Download Paper: https://medic.upm.edu.my/upload/dokumen/2023111509...
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Additional Metadata
| Item Type: | Article |
|---|---|
| Divisions: | Faculty of Veterinary Medicine |
| Publisher: | Universiti Putra Malaysia Press |
| Keywords: | Mesenchymal stem cells; Extracellular vesicles; Exosomes; Ophthalmology; Penetration; Exosome eye drops; Ocular tissue; CD63 marker; Good health and well-being |
| Depositing User: | Mr. Mohamad Syahrul Nizam Md Ishak |
| Date Deposited: | 13 Jun 2024 02:54 |
| Last Modified: | 13 Jun 2024 02:54 |
| URI: | http://psasir.upm.edu.my/id/eprint/110589 |
| Statistic Details: | View Download Statistic |
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