UPM Institutional Repository

Role of the IL8 rs4073 polymorphism in central nervous system toxicity in patients receiving multidrug-resistant tuberculosis treatment


Citation

Mohammed Badamasi, Ibrahim and Muhammad, Muktar and Ahmad Umar, Aishat and Misbahu Madugu, Umm-ayman and Ahmed Gadanya, Muktar and Abubakar Aliyu, Isa and Malik Kabir, Imam and Aliyu Umar, Ibrahim and Johnson, Ochigbo and Stanslas, Johnson (2024) Role of the IL8 rs4073 polymorphism in central nervous system toxicity in patients receiving multidrug-resistant tuberculosis treatment. Jornal Brasileiro de Pneumologia, 49 (6). art. no. e20230338. pp. 1-6. ISSN 1806-3713; ESSN: 1806-3756

Abstract

<jats:p>Objective: To determine the role of the IL8 rs4073 polymorphism in predicting the risk of central nervous system (CNS) toxicity in patients receiving standard pharmacological treatment for multidrug-resistant tuberculosis (MDR-TB). Methods: A cohort of 85 consenting MDR-TB patients receiving treatment with second-line antituberculosis drugs had their blood samples amplified for the IL8 (rs4073) gene and genotyped. All patients were clinically screened for evidence of treatment toxicity and categorized accordingly. Crude and adjusted associations were assessed. Results: The chief complaints fell into the following categories: CNS toxicity; gastrointestinal toxicity; skin toxicity; and eye and ear toxicities. Symptoms of gastrointestinal toxicity were reported by 59% of the patients, and symptoms of CNS toxicity were reported by 42.7%. With regard to the genotypes of IL8 (rs4073), the following were identified: AA, in 64 of the study participants; AT, in 7; and TT, in 11. A significant association was found between the dominant model of inheritance and CNS toxicity for the crude model (p = 0.024; OR = 3.57; 95% CI, 1.18-10.76) and the adjusted model (p = 0.031; OR = 3.92; 95% CI, 1.13-13.58). The AT+TT genotype of IL8 (rs4073) showed a 3.92 times increased risk of CNS toxicity when compared with the AA genotype. Conclusions: The AT+TT genotype has a tendency to be associated with an increased risk of adverse clinical features during MDR-TB treatment.</jats:p>


Download File

Full text not available from this repository.

Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
DOI Number: https://doi.org/10.36416/1806-3756/e20230338
Publisher: Sociedade Brasileira de Pneumologia e Tisiologia
Keywords: Tuberculosis; Multidrug-resistant; Immunity; Pharmacogenetics; Polymerase chain reaction; Risk; Good health and well-being
Depositing User: Mr. Mohamad Syahrul Nizam Md Ishak
Date Deposited: 16 Jun 2024 03:00
Last Modified: 16 Jun 2024 03:00
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.36416/1806-3756/e20230338
URI: http://psasir.upm.edu.my/id/eprint/110524
Statistic Details: View Download Statistic

Actions (login required)

View Item View Item