Citation
Abstract
Zoonotic disease dynamics in wildlife hosts are rarely quantified at macroecological scales due to the lack of systematic surveys. Non-human primates (NHPs) host <jats:italic>Plasmodium knowlesi,</jats:italic> a zoonotic malaria of public health concern and the main barrier to malaria elimination in Southeast Asia. Understanding of regional <jats:italic>P. knowlesi</jats:italic> infection dynamics in wildlife is limited. Here, we systematically assemble reports of NHP <jats:italic>P. knowlesi</jats:italic> and investigate geographic determinants of prevalence in reservoir species. Meta-analysis of 6322 NHPs from 148 sites reveals that prevalence is heterogeneous across Southeast Asia, with low overall prevalence and high estimates for Malaysian Borneo. We find that regions exhibiting higher prevalence in NHPs overlap with human infection hotspots. In wildlife and humans, parasite transmission is linked to land conversion and fragmentation. By assembling remote sensing data and fitting statistical models to prevalence at multiple spatial scales, we identify novel relationships between <jats:italic>P. knowlesi</jats:italic> in NHPs and forest fragmentation. This suggests that higher prevalence may be contingent on habitat complexity, which would begin to explain observed geographic variation in parasite burden. These findings address critical gaps in understanding regional <jats:italic>P. knowlesi</jats:italic> epidemiology and indicate that prevalence in simian reservoirs may be a key spatial driver of human spillover risk.
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Official URL or Download Paper: https://elifesciences.org/articles/88616
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Additional Metadata
Item Type: | Article |
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Divisions: | Faculty of Veterinary Medicine |
DOI Number: | https://doi.org/10.7554/elife.88616 |
Publisher: | eLife Sciences Publications |
Keywords: | Disease ecology; Ecology; Epidemiology; Forest fragmentation; Global health; Landscape change; Macaca fascicularis; Malaria; Plasmodium knowlesi |
Depositing User: | Ms. Che Wa Zakaria |
Date Deposited: | 26 Sep 2024 08:29 |
Last Modified: | 26 Sep 2024 08:29 |
Altmetrics: | http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.7554/elife.88616 |
URI: | http://psasir.upm.edu.my/id/eprint/108884 |
Statistic Details: | View Download Statistic |
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