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In silico identification of prospective virulence factors associated with candidiasis in Meyerozyma guilliermondii strain SO from genome dataset


Citation

Zainudin, Robiatul Azilah and Sabri, Suriana and Salleh, Abu Bakar and Abu, Arpah and Raja Khairuddin, Raja Farhana and Oslan, Siti Nurbaya (2023) In silico identification of prospective virulence factors associated with candidiasis in Meyerozyma guilliermondii strain SO from genome dataset. Egyptian Journal of Medical Human Genetics, 24 (6). art. no. 6. pp. 1-13. ISSN 1110-8630; eISSN: 2090-2441

Abstract

Meyerozyma guilliermondii is a prospective yeast that has extensively contributed to the biotechnology sector. In 2015, M. guilliermondii strain SO which was isolated from spoiled orange has successfully been developed as an inducer-free expression system and attained a significant impact in producing industrially important recombinant proteins. The species possesses high similarity to Candida albicans which may cause candidiasis. The industrial-benefiting M. guilliermondii strain SO has been underexplored for its virulence status. Thus, this study aimed to document the potential virulence factors through the comprehensive in silico analysis of M. guilliermondii strain SO genome. This analysis demonstrated the molecular characterization which could distinguish the pathogenicity status of M. guilliermondii.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Biotechnology and Biomolecular Sciences
DOI Number: https://doi.org/10.1186/s43042-023-00384-3
Publisher: SpringerOpen
Keywords: Virulence factors; Whole genome sequencing; Yeast expression system; Meyerozyma guilliermondii; Good health and well-being; Life on land
Depositing User: Ms. Che Wa Zakaria
Date Deposited: 11 Oct 2024 08:50
Last Modified: 11 Oct 2024 08:50
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1186/s43042-023-00384-3
URI: http://psasir.upm.edu.my/id/eprint/108816
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