Citation
Baharuddin, Fatin Farhana and Mad Nasir, Nadiah and Tejo, Bimo Ario and Koh, Soo Peng and Ramakrishnan, Shuruti and Nordin, Nur Qurratu Ain A. and Adzahar, Anis Nasuha and Devakrishnan, Pavithren and Mohd Razib, Salsabiilaa
(2023)
Potent halogenated xanthone derivatives: synthesis, molecular docking and study on antityrosinase activity.
Journal of Asian Natural Products Research, 26 (5).
pp. 575-582.
ISSN 1028-6020; ESSN: 1477-2213
Abstract
Tyrosinase inhibitors can reduce melanin production for skin whitening, but some existing products may harm the skin. This study discovered six compounds that inhibit tyrosinase in the mushroom Agaricus bisporus by over 50%. Compound 11 displayed strong inhibition (92.2% and 86.7%) for L-tyrosine and L-DOPA substrates, while compound 13 showed high inhibition (96.0% and 62.0%) for both substrates. Molecular docking simulations revealed compounds 11 and 13 bind at the allosteric site of the enzyme. Xanthone derivatives, based on these findings, hold potential as safe skin whitening agents and for pigmentation-related diseases in the cosmetic industry.
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Additional Metadata
| Item Type: | Article |
|---|---|
| Divisions: | Faculty of Science |
| DOI Number: | https://doi.org/10.1080/10286020.2023.2264784 |
| Publisher: | Taylor and Francis Group |
| Keywords: | Anti-tyrosinase; Xanthones; Docking; Good health and well-being |
| Depositing User: | Ms. Che Wa Zakaria |
| Date Deposited: | 11 Oct 2024 08:24 |
| Last Modified: | 11 Oct 2024 08:24 |
| Altmetrics: | http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1080/10286020.2023.2264784 |
| URI: | http://psasir.upm.edu.my/id/eprint/108720 |
| Statistic Details: | View Download Statistic |
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