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Exploring the therapeutic and anti-tumor properties of morusin: a review of recent advances


Citation

Hafeez, Amna and Khan, Zeeshan and Armaghan, Muhammad and Khan, Khushbukhat and Sönmez Gürer, Eda and Abdull Razis, Ahmad Faizal and Modu, Babagana and Almarhoon, Zainab M. and Setzer, William N. and Sharifi-Rad, Javad (2023) Exploring the therapeutic and anti-tumor properties of morusin: a review of recent advances. Frontiers in Molecular Biosciences, 10. pp. 1-17. ISSN 2296-889X; eISSN: 2296-889X

Abstract

Morusin is a natural product that has been isolated from the bark of Morus alba, a species of mulberry tree. It belongs to the flavonoid family of chemicals, which is abundantly present in the plant world and is recognized for its wide range of biological activities. Morusin has a number of biological characteristics, including anti-inflammatory, anti-microbial, neuro-protective, and antioxidant capabilities. Morusin has exhibited anti-tumor properties in many different forms of cancer, including breast, prostate, gastric, hepatocarcinoma, glioblastoma, and pancreatic cancer. Potential of morusin as an alternative treatment method for resistant malignancies needs to be explored in animal models in order to move toward clinical trials. In the recent years several novel findings regarding the therapeutic potential of morusin have been made. This aim of this review is to provide an overview of the present understanding of morusin’s beneficial effects on human health as well as provide a comprehensive and up-to-date discussion of morusin’s anti-cancer properties with a special focus on in vitro and in vivo studies. This review will aid future research on the creation of polyphenolic medicines in the prenylflavone family, for the management and treatment of cancers.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Food Science and Technology
DOI Number: https://doi.org/10.3389/fmolb.2023.1168298
Publisher: Frontiers Media S.A.
Keywords: Morusin; Natural compound; Anti-cancer activity; Polyphenol; Resistant malignancies
Depositing User: Ms. Zaimah Saiful Yazan
Date Deposited: 05 Mar 2025 00:06
Last Modified: 05 Mar 2025 00:06
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.3389/fmolb.2023.1168298
URI: http://psasir.upm.edu.my/id/eprint/107907
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