Citation
Abstract
Polymeric micelles (PM) are amphiphilic block copolymers that can form nanoscopic core/shell structures, making them highly effective for drug delivery systems (DDS). Multi-armed starshaped poly(ethylene glycol) (PEG) polymers, a promising type of PM, provide a regulated release of drugs and can be integrated with numerous endpoints to create multifunctional drug delivery systems capable of transporting a large number of drugs. Star-PEG polymers can also be cross-linked to create three dimensional hydrogels with variable functionalities and sizes, increasing blood flow and reducing unanticipated drug release. In this review, we present state-of-the-art computational tools for analyzing drug pharmacokinetic profiles and identifying molecular interactions critical for successful drug encapsulation in star-PEG PM. By taking into account the features described, academic and industrial researchers can identify novel interrelationships in PM and maximize their capabilities as DDSs for systemic administration, ultimately enhancing the medicinal qualities of drug delivery.
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Additional Metadata
Item Type: | Article |
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Divisions: | Institut Nanosains dan Nanoteknologi |
DOI Number: | https://doi.org/10.1002/slct.202301022 |
Publisher: | John Wiley and Sons |
Keywords: | Computational techniques; DDS; Drug encapsulation; Polymeric micelles; Star-shaped PEG; Industry; Innovation and infrastructure |
Depositing User: | Ms. Che Wa Zakaria |
Date Deposited: | 11 Oct 2024 08:58 |
Last Modified: | 11 Oct 2024 08:58 |
Altmetrics: | http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1002/slct.202301022 |
URI: | http://psasir.upm.edu.my/id/eprint/106491 |
Statistic Details: | View Download Statistic |
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