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Genomic surveillance of omicron B.1.1.529 SARS-CoV-2 and its variants between December 2021 and March 2023 in Tamil Nadu, India—A state-wide prospective longitudinal study


Citation

Selvavinayagam, Sivaprakasam T. and Suvaithenamudhan, Suvaiyarasan and Yong, Yean K. and Hemashree, Kannan and Rajeshkumar, Manivannan and Kumaresan, Anandhazhvar and Arthydevi, Parthiban and Kannan, Meganathan and Gopalan, Natarajan and Vignesh, Ramachandran and Murugesan, Amudhan and Sivasankaran, Munusamy P. and Sankar, Sathish and Cheedarla, Narayanaiah and Anshad, Abdul R. and Govindaraj, Sakthivel and Zhang, Ying and Tan, Hong Y. and Larsson, Marie and Saravanan, Shanmugam and Balakrishnan, Pachamuthu and Kulanthaivel, Langeswaran and Singh, Kamalendra and Joseph, Narcisse and Velu, Vijayakumar and Byrareddy, Siddappa N. and Shankar, Esaki M. and Raju, Sivadoss (2024) Genomic surveillance of omicron B.1.1.529 SARS-CoV-2 and its variants between December 2021 and March 2023 in Tamil Nadu, India—A state-wide prospective longitudinal study. Journal of Medical Virology, 96 (2). art. no. 29456. ISSN 0146-6615; eISSN: 1096-9071

Abstract

A state-wide prospective longitudinal investigation of the genomic surveillance of the omicron B.1.1.529 SARS-CoV-2 variant and its sublineages in Tamil Nadu, India, was conducted between December 2021 and March 2023. The study aimed to elucidate their mutational patterns and their genetic interrelationship in the Indian population. The study identified several unique mutations at different time-points, which likely could attribute to the changing disease characteristics, transmission, and pathogenicity attributes of omicron variants. The study found that the omicron variant is highly competent in its mutating potentials, and that it continues to evolve in the general population, likely escaping from natural as well as vaccine-induced immune responses. Our findings suggest that continuous surveillance of viral variants at the global scenario is warranted to undertake intervention measures against potentially precarious SARS-CoV-2 variants and their evolution.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
DOI Number: https://doi.org/10.1002/jmv.29456
Publisher: Wiley
Keywords: COVID-19; Genomics; Humans; India; Longitudinal Studies; Prospective Studies; SARS-CoV-2; SARS-CoV-2 variants; vitronectin; amino terminal sequence; Article; binding affinity; controlled study; disease severity; gene cluster; immune response; India; longitudinal study; molecular phylogeny; mutational analysis; nonhuman; prediction; prospective study; protein domain; receptor binding domain; SARS-CoV-2 Omicron; virus genome; virus mutation; virus transmission; virus virulence; coronavirus disease 2019; genetics; genomics; human; Severe acute respiratory syndrome coronavirus 2
Depositing User: Ms. Nuraida Ibrahim
Date Deposited: 18 Nov 2024 02:10
Last Modified: 18 Nov 2024 02:10
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1002/jmv.29456
URI: http://psasir.upm.edu.my/id/eprint/106098
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