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Fractional exhaled nitric oxide (FeNO) and respiratory symptoms in junior high school students in Penang, Malaysia: the role of household exposure


Citation

Norback, Dan and Hashim, Jamal Hisham and Hashim, Zailina and Wieslander, Gunilla (2024) Fractional exhaled nitric oxide (FeNO) and respiratory symptoms in junior high school students in Penang, Malaysia: the role of household exposure. International Journal of Environmental Health Research, 34 (1). pp. 213-224. ISSN 0960-3123; ESSN: 1369-1619

Abstract

We studied associations between fractional exhaled nitric oxide (FeNO), health and household exposure among school children (N = 348) in Penang, Malaysia. Multiple logistic regression and linear mixed models were applied. Overall, 46.0 had elevated FeNO (>20 ppb) and 10.6 diagnosed asthma. Male gender (p = 0.002), parental asthma or allergy (p = 0.047), cat allergy (p = 0.009) and seafood allergy (p < 0.001), diagnosed asthma (p = 0.001), wheeze (p = 0.001), ocular symptoms (p = 0.001), rhinitis (p = 0.002) and respiratory infections (p = 0.004) were all associated with FeNO. Students exposed to ETS had lower FeNO (p = 0.05). Dampness and mould was associated with wheeze (p = 0.038), especially in wooden homes (interaction p = 0.042) and among students with elevated FeNO (interaction p = 0.024). Cat keeping increased rhinitis (p = 0.041) and respiratory infections (p = 0.008) and modified the dampness associations. In conclusion, FeNO can be associated with ocular and respiratory symptoms. Elevated FeNO, cat keeping and a wooden house can enhance the risk of wheeze when exposed to dampness and mould.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
DOI Number: https://doi.org/10.1080/09603123.2022.2143482
Publisher: Taylor and Francis Ltd.
Keywords: Allergy; Asthma; Malaysia; Rhinitis; Tropical country; Nitric oxide; FeNO; Fractional exhaled nitric oxide; Respiratory symptoms; Junior high school students; Penang; Malaysia; Household exposure
Depositing User: Mr. Mohamad Syahrul Nizam Md Ishak
Date Deposited: 27 Mar 2024 09:22
Last Modified: 12 Jul 2024 08:15
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1080/09603123.2022.2143482
URI: http://psasir.upm.edu.my/id/eprint/105880
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