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Fetal acalvaria with lateral cleft lip and palate: a rare presentation


Citation

Mohd Jamil, Amilia Afzan and Chua, Wang Ching and Valayudham, Vairavan Ramesh and Abu Hassan, Hasyma and Abdul Jalal, Hamidah (2024) Fetal acalvaria with lateral cleft lip and palate: a rare presentation. Radiology Case Reports, 19 (1). pp. 374-377. ISSN 1930-0433

Abstract

We report a case of acalvaria diagnosed prenatally via ultrasound and MRI. Acalvaria is a rare, fatal congenital condition characterized by the absence of flat bones of the cranial vault, dura mater, and its associated muscles with an intact central nervous system. A 41-year-old gravida 5, para 2 + 2A, presented to us at 26 weeks gestation age (GA) with ultrasound findings of a fragile and hypomineralized skull in the fetus. The patient was not keen on whole-axon sequencing. Fetus magnetic resonance imaging (MRI) revealed large cutaneous/skull nonvisualization of the fetus skull, possibly acrania without anencephaly. She delivered via cesarean section at 37 weeks because of two previous cesarean sections. A female infant weighing 2650 g was born with an intact sac to minimize excessive external pressure to the brain tissue. A diagnosis of acalvaria with bilateral lateral cleft lip and palate was made postdelivery. The infant was managed conservatively per multidisciplinary discussion and expired 3 weeks later.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
DOI Number: https://doi.org/10.1016/j.radcr.2023.10.036
Publisher: Elsevier Inc.
Keywords: Acalvaria; Fetal MRI; Prenatal diagnosis; Transverse cleft lip and palate; Adult; Anencephalus; Brain malformation; Brain tissue; Case report; Cesarean section; Cleft lip palate; Conservative treatment; Female; Fetus; Fetus brain; Fetus mortality; Gestational age; Nuclear magnetic resonance imaging; Prenatal diagnosis; Three dimensional echography
Depositing User: Mr. Mohamad Syahrul Nizam Md Ishak
Date Deposited: 27 Mar 2024 01:15
Last Modified: 15 Jul 2024 04:19
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1016/j.radcr.2023.10.036
URI: http://psasir.upm.edu.my/id/eprint/105870
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