Citation
Abstract
The attractive properties of gadolinium-based nanoparticles as a positive contrast agent for magnetic resonance imaging (MRI) have piqued the interest of both researchers and clinicians. Nonetheless, due to the biotoxicity of gadolinium (III) ions' free radicals, there is a need to address this issue. Therefore, this research aimed to develop a biocompatible, dispersible, stable, hydrophilic, and less toxic cellulose nanocrystals/gadolinium oxide nanocomposite as contrast agent properties for MRI purposes. This study aimed to synthesize gadolinium oxide nanoparticles coated with cellulose nanocrystals with polyethylene glycol and sodium hydroxide (CNCs-PEG/NaOH)/Gd2O3 using the gamma irradiation method to reduce the particle size. The results showed that using a gamma irradiation dose of 10 kGy, quasi-spherical morphology with a size of approximately 5.5 ± 0.65 nm could be produced. Furthermore, the cytocompatibility of (CNCs-PEG/NaOH)/Gd2O3 nanocomposite synthesized was assessed through MTT assay tests on Hep G2 cells, which demonstrated good cytocompatibility without any cytotoxic effects within a concentration range of (10 μg/mL −150 μg/mL) and had sufficient cellular uptake. Moreover, the T1-weighted MRI of (CNCs-PEG/NaOH)/Gd2O3 nanocomposite revealed promising results as a positive contrast agent. It is envisaged that the gamma irradiation method is promising in synthesizing (CNCs-PEG/NaOH)/Gd2O3 nanocomposite with nanoscale for different applications, especially in the radiotherapy field.
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Additional Metadata
Item Type: | Article |
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Divisions: | Faculty of Medicine and Health Science Hospital Pengajar UPM |
DOI Number: | https://doi.org/10.1016/j.net.2023.12.037 |
Publisher: | Korean Nuclear Society |
Keywords: | Gadolinium oxide nanoparticles; Cellulose nanocrystals; Gamma irradiation-reduction method; Contrast agent; Nanocomposite |
Depositing User: | Mr. Mohamad Syahrul Nizam Md Ishak |
Date Deposited: | 24 May 2024 01:31 |
Last Modified: | 12 Jul 2024 07:16 |
Altmetrics: | http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1016/j.net.2023.12.037 |
URI: | http://psasir.upm.edu.my/id/eprint/105845 |
Statistic Details: | View Download Statistic |
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