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Effect of gamma irradiation on the size of cellulose nanocrystals with polyethylene glycol and sodium hydroxide/Gd2O3 nanocomposite as contrast agent in magnetic resonance imaging (MRI)


Citation

Whba, Fathyah and Mohamed, Faizal and Idris, Mohd Idzat and Whba, Rawdah and Mohd Noor, Noramaliza (2024) Effect of gamma irradiation on the size of cellulose nanocrystals with polyethylene glycol and sodium hydroxide/Gd2O3 nanocomposite as contrast agent in magnetic resonance imaging (MRI). Nuclear Engineering and Technology. pp. 1-10. ISSN 1738-5733; ESSN: 2234-358X (In Press)

Abstract

The attractive properties of gadolinium-based nanoparticles as a positive contrast agent for magnetic resonance imaging (MRI) have piqued the interest of both researchers and clinicians. Nonetheless, due to the biotoxicity of gadolinium (III) ions' free radicals, there is a need to address this issue. Therefore, this research aimed to develop a biocompatible, dispersible, stable, hydrophilic, and less toxic cellulose nanocrystals/gadolinium oxide nanocomposite as contrast agent properties for MRI purposes. This study aimed to synthesize gadolinium oxide nanoparticles coated with cellulose nanocrystals with polyethylene glycol and sodium hydroxide (CNCs-PEG/NaOH)/Gd2O3 using the gamma irradiation method to reduce the particle size. The results showed that using a gamma irradiation dose of 10 kGy, quasi-spherical morphology with a size of approximately 5.5 ± 0.65 nm could be produced. Furthermore, the cytocompatibility of (CNCs-PEG/NaOH)/Gd2O3 nanocomposite synthesized was assessed through MTT assay tests on Hep G2 cells, which demonstrated good cytocompatibility without any cytotoxic effects within a concentration range of (10 μg/mL −150 μg/mL) and had sufficient cellular uptake. Moreover, the T1-weighted MRI of (CNCs-PEG/NaOH)/Gd2O3 nanocomposite revealed promising results as a positive contrast agent. It is envisaged that the gamma irradiation method is promising in synthesizing (CNCs-PEG/NaOH)/Gd2O3 nanocomposite with nanoscale for different applications, especially in the radiotherapy field.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
Hospital Pengajar UPM
DOI Number: https://doi.org/10.1016/j.net.2023.12.037
Publisher: Korean Nuclear Society
Keywords: Gadolinium oxide nanoparticles; Cellulose nanocrystals; Gamma irradiation-reduction method; Contrast agent; Nanocomposite
Depositing User: Mr. Mohamad Syahrul Nizam Md Ishak
Date Deposited: 24 May 2024 01:31
Last Modified: 12 Jul 2024 07:16
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1016/j.net.2023.12.037
URI: http://psasir.upm.edu.my/id/eprint/105845
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