Citation
Abstract
In this study, the potential neuroprotective ability of coriander seeds (Coriandrum sativum L.) ethanolic extract (CSES) as a neuroprotectant agent in the brains of high-fat diet-induced obese rats was analyzed. The study investigated how CSES impacts oxidative stress markers (i.e., malondialdehyde/MDA, glutathione/GSH and catalase), inflammation marker (i.e., Interleukin-6/IL-6), cellular senescence markers (i.e., senescence-associated β-galactoside/SA-β-Gal activity and p16), brain damage marker (i.e., Neuron-specific Enolase/NSE), and neurogenesis markers (i.e., mature Brain-derived Neurotropic Factor/BDNF, pro-BDNF, and mature/pro-BDNF ratio). Male adult Wistar rats were fed a high-fat diet and given CSES once daily, at 100 mg/kg body weight, for 12 weeks. CSES significantly reduced MDA concentration (p = < 0.001), SA-β-Gal activity (p = 0.010), and increased GSH concentration (p = 0.047) in the brain of obese rats; however, the decrease of IL-6, NSE, and p16 as well as the increase of catalase specific activity and BDNF expression were not significant. Moreover, the mature/pro-BDNF ratio was significantly higher in the brains of non-obese rats, both given the control diet and the high-fat diet compared to the control. Our results suggest that obese rats benefited from consuming CSES, showing improved oxidative stress levels, reduced cellular senescence and increased endogenous antioxidants, making CSES a potential neuroprotective agent.
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Official URL or Download Paper: https://www.nature.com/articles/s41598-024-51221-5...
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Additional Metadata
Item Type: | Article |
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Divisions: | Faculty of Science |
DOI Number: | https://doi.org/10.1038/s41598-024-51221-5 |
Publisher: | Nature Research |
Keywords: | Animals; Brain; Brain-derived neurotrophic factor; Catalase; Coriandrum; Ethanol; Glutathione; Interleukin-6; Male; Neuroprotective agents; Obesity; Rats; Seeds; Alcohol; Biochemistry; Molecular biology; Neuroscience |
Depositing User: | Mohamad Jefri Mohamed Fauzi |
Date Deposited: | 09 May 2024 03:28 |
Last Modified: | 09 May 2024 03:28 |
Altmetrics: | http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1038/s41598-024-51221-5 |
URI: | http://psasir.upm.edu.my/id/eprint/105629 |
Statistic Details: | View Download Statistic |
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