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Preparation, characterisation and antibacterial activity of carvacrol encapsulated in gellan gum hydrogel


Citation

Jaafar, Adila Mohamad and Hasnu, Norafida and Zainal, Zulkarnain and Masarudin, Mas Jaffri and Md. Ajat, Mohd Mokrish and Aung, Min Min and Rayung, Marwah (2021) Preparation, characterisation and antibacterial activity of carvacrol encapsulated in gellan gum hydrogel. Polymers, 13 (23). art. no. 4153. pp. 1-14. ISSN 2073-4360

Abstract

Recently, the antibacterial properties of Carvacrol (Carv) have been significantly reported. However, due to the unstable properties of Carv under various environment conditions, research approaches tailored towards its widespread and efficient use in various antimicrobial applications are scarce. Here, we discuss progress towards overcoming this challenge by utilising the encapsulation of Carv in gellan gum hydrogels to form thin films (GG-Carv) containing different concentrations of Carv (0.01–0.32 M). FTIR spectrum of GG-Carv revealed that both functional groups from GG and Carv existed. The carbon, hydrogen and nitrogen elemental analysis further supported the encapsulation of Carv with the changes in the element percentage of GG-Carv. Both swelling and degradation percentage increased with time and the decreasing patterns were observed as the concentration of Carv increased. In an antibacterial study, GG-Carv exhibited significant antibacterial activity against E. coli with the clear inhibition zone of 200 mm and the detection of bacterial growth showed enhancement with continuous decline throughout the study as compared to free-standing Carv.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Biotechnology and Biomolecular Sciences
Faculty of Science
Faculty of Veterinary Medicine
Institute of Tropical Forestry and Forest Products
Centre of Foundation Studies for Agricultural Science
DOI Number: https://doi.org/10.3390/polym13234153
Publisher: MDPI
Keywords: Encapsulated carvacrol; Polymer; Gellan gum hydrogel; Antibacterial activity; E. coli
Depositing User: Mr. Mohamad Syahrul Nizam Md Ishak
Date Deposited: 23 Jun 2024 00:31
Last Modified: 23 Jun 2024 00:31
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.3390/polym13234153
URI: http://psasir.upm.edu.my/id/eprint/102858
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