Potential use of integrated multimodality imaging 18F-FDG PET-CT in the evaluation of inflammatory bowel disease: a brief report

Inflammatory bowel disease (IBD) significantly increases the risk of colorectal cancer (CRC) due to an inappropriate, aberrantresponse of the mucosal immune system that can cause chronic irritation and malignant transformation. This prospectivestudy included 8 patients who presented at the Gastroenterology Clinic of Serdang Hospital in Malaysia with a prolonged history of altered bowel habits. Blood tests, endoscopy, tissue biopsy, and whole-body positron emission tomography-computedtomography (PET-CT) using fluorodeoxyglucose F 18 (18F-FDG) as biomarker for tumor imaging were performed. Therewas a correlation between a high maximum standardized uptake value with contrast-enhanced CT changes, endoscopic, anderythrocyte sedimentation rate findings and clinical presentation. The sensitivity and negative predictive value of 18F-FDGPET-CT were 100%. 18F-FDG PET-CT is a promising, noninvasive method that complements endoscopy in the investigationof IBD and may perhaps play a role as a gatekeeper

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