Citation
Abstract
In recent years, long non-coding RNAs (lncRNAs) have been shown to play important regulatory roles in cellular processes. Growth arrests specific transcript 5 (GAS5) is a lncRNA that is highly expressed during the cell cycle arrest phase but is downregulated in actively growing cells. Growth arrests specific transcript 5 was discovered to be downregulated in several cancers, primarily solid tumors, and it is known as a tumor suppressor gene that regulates cell proliferation, invasion, migration, and apoptosis via multiple molecular mechanisms. Furthermore, GAS5 polymorphism was found to affect GAS5 expression and functionality in a cell-specific manner. This review article focuses on GAS5’s tumor-suppressive effects in regulating oncogenic signaling pathways, cell cycle, apoptosis, tumor-associated genes, and treatment-resistant cells. We also discussed genetic polymorphisms of GAS5 and their association with cancer susceptibility.
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Official URL or Download Paper: https://www.mdpi.com/2311-553X/8/3/39
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Additional Metadata
| Item Type: | Article |
|---|---|
| Divisions: | Faculty of Biotechnology and Biomolecular Sciences |
| DOI Number: | https://doi.org/10.3390/ncrna8030039 |
| Publisher: | MDPI AG |
| Keywords: | lncRNA; growth-arrest specific transcript 5; GAS5; tumor suppressor; polymorphism; Cancer regulation; Oncogenic signaling pathways; Cell cycle control; Apoptosis regulation; Genetic polymorphisms; Cancer susceptibility |
| Depositing User: | Mr. Mohamad Syahrul Nizam Md Ishak |
| Date Deposited: | 12 Mar 2024 09:24 |
| Last Modified: | 12 Mar 2024 09:24 |
| Altmetrics: | http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.3390/ncrna8030039 |
| URI: | http://psasir.upm.edu.my/id/eprint/102517 |
| Statistic Details: | View Download Statistic |
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