Citation
Abstract
An undescribed conjugated sesquiterpene, amelicarin (1), together with nine known compounds (2–10) were isolated for the first time from Melicope latifolia. Their structures were elucidated by extensive NMR spectroscopic and mass spectrometric methods. The conjugated sesquiterpene possesses a unique 6/6/9/4-ring fused tetracyclic skeleton. The proposed biosynthesis pathway of 1 consist of three reactions steps: (1) polyketide formation, (2) cyclisation and (3) addition to form the conjugated sesquiterpenoid as final metabolite. Out of the ten isolated metabolites, amelicarin (1) showed activity against 4 cancerous cell lines namely SK-MEL skin cancer, KB oral cancer, BT-549 breast cancer, and SK-OV-3 ovarian cancer with IC50 values between 15 and 25 µg/mL.
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Official URL or Download Paper: https://www.tandfonline.com/doi/abs/10.1080/147864...
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Additional Metadata
| Item Type: | Article |
|---|---|
| Divisions: | Faculty of Science |
| DOI Number: | https://doi.org/10.1080/14786419.2021.1885031 |
| Publisher: | Taylor and Francis |
| Keywords: | Melicope latifolia; Rutaceae; Conjugated sesquiterpene; Isolation; Cytotoxicity |
| Depositing User: | Ms. Nur Faseha Mohd Kadim |
| Date Deposited: | 17 Aug 2023 04:21 |
| Last Modified: | 17 Aug 2023 04:21 |
| URI: | http://psasir.upm.edu.my/id/eprint/100866 |
| Statistic Details: | View Download Statistic |
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