Design of novel semisynethetic metalloenzyme from thermolysin
Abdul Rahman, Mohd Basyaruddin and Jaafar, Ahmad Haniff and Basri, Mahiran and Raja Abdul Rahman, Raja Noor Zaliha and Salleh, Abu Bakar and Abdul Wahab, Habibah (2007) Design of novel semisynethetic metalloenzyme from thermolysin. In: BioSysBio 2007: Systems Biology, Bioinformatics, Synthetic Biology, 11-13 Jan. 2007, Manchester, UK.
Initial applications of biocatalysis involved the used of naturally occurring enzyme. With new challenges in green chemical reaction, biocatalyst that shed the light is metalloenzyme,which function as enzyme and contain metal that are tightly attached and always isolated with the protein. In recent years, enzyme engineering has proven to be an invaluable tool for elucidating biocatalytic mechanisms as well as producing enzymes for industrial purposes.Approaches developed for in vivo chemical modification and in silico computational methods promise to increase the scope and have already been used successfully to alter existing protein so that they have better stability and functionality . This task might be good to address in designing a new biocatalyst with improved properties.
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