Existence of Two Form of L Protein of Newcastle Disease Virus Isolates Due to a Compensatory Mutation in Domain V
Kusumaningtyas, Eni and Tan, Wen Siang and Zamrod, Zulkeflie and Eshaghi, Majid and Yusoff, Khatijah (2004) Existence of Two Form of L Protein of Newcastle Disease Virus Isolates Due to a Compensatory Mutation in Domain V. Archives of Virology, 149 (1). pp. 1859-1865. ISSN 0304-8608
Official URL: http://dx.doi.org/10.1007/s00705-004-0336-5
Summary. Nucleotide sequence comparison of the L gene of the Malaysian neurotropic-viscerotropic velogenic NDV strain AF2240 with other NDV strains revealed a single nucleotide insertion at position 3870. This mutation is compensated by a nucleotide deletion downstream at position 3958 which results in two forms of the L proteins containing a 30-amino acid substitution in Domain V. This compensatory mutation this does not correlate with the pathogenicity of the viral strains but is may affect the viral replication as Domain V is believed to play an important role in the replication of paramyxoviruses.
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