Semisynthesis of Andrographolide Derivatives and Evaluation of Their Antitumour Properties

Rao, Jada Srinivasa (2004) Semisynthesis of Andrographolide Derivatives and Evaluation of Their Antitumour Properties. PhD thesis, Universiti Putra Malaysia.

[img] PDF
933Kb

Abstract

Previously, andrographolide, which is the major diterpenoid of Andrographis paniculata, was shown to have in vivo antitumour activity against human breast tumour xenografts. In this study, among the four compounds isolated from A. paniculata, andrographolide was the most potent compound with a mean ICso value of 8 IlM in MCF-7 human breast cancer cells. Neoandrographolide showed a weak cytotoxic effect, whereas 14-deoxy-ll, 12-didehydroandrographolide and 14-deoxyandrographolide failed to exhibit growth inhibitory effect at the highest tested concentration of 100 IlM. Owing to this, andrographolide was considered as the lead compound in the discovery of potent and selective antitumour agents. Using andrographolide isolated from A. paniculata as one of the starting materials, 3,19-

Item Type:Thesis (PhD)
Chairman Supervisor:Associate Professor Nasaruddin bin Abdul Aziz, M.D. M.Med. Sc.
Call Number:FPSK(P) 2004 8
Faculty or Institute:Faculty of Medicine and Health Science
ID Code:6584
Deposited By: Nur Izzati Mohd Zaki
Deposited On:19 May 2010 07:30
Last Modified:27 May 2013 07:30

Repository Staff Only: Edit item detail

Document Download Statistics

This item has been downloaded for since 19 May 2010 07:30.

View statistics for "Semisynthesis of Andrographolide Derivatives and Evaluation of Their Antitumour Properties"


Universiti Putra Malaysia Institutional Repository

Universiti Putra Malaysia Institutional Repository is an on-line digital archive that serves as a central collection and storage of scientific information and research at the Universiti Putra Malaysia.

Currently, the collections deposited in the IR consists of Master and PhD theses, Master and PhD Project Report, Journal Articles, Journal Bulletins, Conference Papers, UPM News, Newspaper Cuttings, Patents and Inaugural Lectures.

As the policy of the university does not permit users to view thesis in full text, access is only given to the first 24 pages only.