Synthesis, Characterisation and Biological Activities Ofmixed-Ligand Copper(II) Complexes Containing Saccharin

Begum, Thahira (2005) Synthesis, Characterisation and Biological Activities Ofmixed-Ligand Copper(II) Complexes Containing Saccharin. Masters thesis, Universiti Putra Malaysia.

[img] PDF
1123Kb

Abstract

New mixed-ligand copper(II) saccharinate complexes of HNNS Schiff bases of Smethyldithiocarbazate, S-benzyldithiocarbazate, S-2-picolyldithiocarbazate and S-4- picolyldithiocarbazate were synthesized by reacting [Cu( sa~)~(H~0)~] 'w2Hith~ Oth e appropriate Schiff bases in water-ethanol-methanol mixtures. These complexes were characterized by elemental analysis, conductance, magnetic susceptibility, IR and electronic spectroscopic measurements. Magnetic and spectral results for the complexes support either a four or five-coordinate geometry in which the Schiff bases coordinate as NNS tridentate ligands and the saccharinate anion coordinates as a unidentate N-donor ligand. X-ray crystallographic structural analysis of the copper(I1)saccharinate complex of S-methyl-~-N-(6-methylpyrid-2-yl)methylenedithiocarbazatesh ows that the complex has a distorted square-pyramidal structure in which the Schiff base is coordinated to the copper ion as a tridentate NNS chelating agent via the pyridine nitrogen atom, the azomethine nitrogen atom and the tholate sulphur atom. The fourth and fifth coordination positions of the five-coordinate Cu(I1) ion are occupied by the imino nitrogen of the saccharinate anion and oxygen atom of the aqua ligand. X-ray crystallographic structural analysis of the copper(I1)saccharinate complex of S-benzyl-0- N-(2-acetylpyndyl)methylenedithiocarb~ shows that ths complex has a distorted square-planar structure in whch the Schiff base is also coordinated to the copper ion as a tridentate NNS chelating agent with the fourth coordination position of the fourcoordinate Cu(II) ion being occupied by the imino nitrogen of the saccharinate anion. The complexes have been evaluated for their biologcal activities against seven pathogenic microbials and three cancer cell lines, KL-60 (Human myeloid leukemic cells), MCF-7 (Human breast carcinoma cells with positive estrogen receptor) and Caov-3 (Human ovarian adenocarcinoma cancer cells). Most of the complexes exhibit marked cytotoxicity against the cell lines and display moderate activity against pathogenic bacteria and h g i .

Item Type:Thesis (Masters)
Chairman Supervisor:Professor Karen A. Crouse, PhD
Call Number:FPSK(M) 2005 21
Faculty or Institute:Faculty of Medicine and Health Science
ID Code:6365
Deposited By: Nur Izzati Mohd Zaki
Deposited On:13 May 2010 06:45
Last Modified:27 May 2013 07:29

Repository Staff Only: item control page

Document Download Statistics

This item has been downloaded for since 13 May 2010 06:45.

View statistics for "Synthesis, Characterisation and Biological Activities Ofmixed-Ligand Copper(II) Complexes Containing Saccharin "


Universiti Putra Malaysia Institutional Repository

Universiti Putra Malaysia Institutional Repository is an on-line digital archive that serves as a central collection and storage of scientific information and research at the Universiti Putra Malaysia.

Currently, the collections deposited in the IR consists of Master and PhD theses, Master and PhD Project Report, Journal Articles, Journal Bulletins, Conference Papers, UPM News, Newspaper Cuttings, Patents and Inaugural Lectures.

As the policy of the university does not permit users to view thesis in full text, access is only given to the first 24 pages only.