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Acetyl-cholinesterase enzyme inhibitory effect of calophyllum species


Citation

Cheng, Gwendoline Lian Ee and Soek, Sin Teh and Siau, Hui Mah and Jamaluddin, Nur Ain and Muhamad Sahimi, Muhamad Syarik and Ahmad, Zuraini (2015) Acetyl-cholinesterase enzyme inhibitory effect of calophyllum species. Tropical Journal of Pharmaceutical Research, 14 (11). pp. 1319-1326. ISSN 1596-5996; ESSN: 1596-9827

Abstract

Purpose: To search for new acetylcholinesterase enzyme inhibitors from Calopyllum species. Methods: Six stem bark extracts of Calophyllum inophyllum, C. soulattri, C. teysmannii, C. lowii, C. benjaminum and C. javanicum were subjected to anti-cholinesterase analysis against acetylcholinesterase (AChE) enzyme using Ellman’s method. Results: Most of the extracts showed promising inhibitory activity against AChE at concentrations of 100 μg/mL, with the methanol extract of C. inophyllum demonstrating the strongest inhibitory effect of 81.28 % followed by the methanol extract of C. benjaminum with 74.32 % inhibition. The methanol extracts of Calophyllum inophyllum and Calophyllum bejaminum also showed significant inhibitory activity towards the acetylcholinesterase (AChE) enzyme. Conclusion: Calophyllum species is capable of yielding potential lead compounds for the development for acetyl-cholinesterase enzyme inhibition drugs.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
Faculty of Science
DOI Number: https://doi.org/10.4314/tjpr.v14i11.8
Publisher: Pharmacotherapy Group, Faculty of Pharmacy, University of Benin
Keywords: Calophyllum species; Acetylcholinesterase; Inhibitors
Depositing User: Mohd Hafiz Che Mahasan
Date Deposited: 22 Jul 2016 02:47
Last Modified: 22 Jul 2016 02:47
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.4314/tjpr.v14i11.8
URI: http://psasir.upm.edu.my/id/eprint/43642
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