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Cytotoxic and anti-tumour promoting activities of carbazole alkaloids from Malayan Murraya koenigii (L.) Spreng

Ahmad, Kartini and Tan, Siow Ping and Md. Sukari, Mohd. Aspollah and Ali, Abdul Manaf and Nafiah, Mohd Azlan (2014) Cytotoxic and anti-tumour promoting activities of carbazole alkaloids from Malayan Murraya koenigii (L.) Spreng. American Journal of Plant Sciences, 5 (19). pp. 2869-2877. ISSN 2158-2742; ESSN: 2158-2750

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Abstract

Murraya koenigii (L.) (Rutaceae) is an indigenous medicinally important herb of Indian origin and now is widely distributed throughout southern Asia. The stem bark, leaves and roots of Malayan Murraya koenigii were selected for phytochemical investigation. Eight carbazole alkaloids was isolated and identified using spectroscopic methods including NMR, IR, UV, MS spectra data. Crude extract and isolated compounds from the roots of this plant were screened for cytotoxic activity and antitumor promoting activity. All crude extracts of the roots including the isolated compounds, mahanimbine, mahanine and murrayafoline-A exhibited significant cytotoxic activity against CEM-SS cell line with IC50 3mg/mL. Girinimbine inhibited EBV-activation in the antitumor promoting assay.

Item Type:Article
Keyword:Carbazole; Rutaceae; Murraya koenigii; NMR; Cytotoxic
Faculty or Institute:Faculty of Science
Publisher:Scientific Research Publishing
DOI Number:10.4236/ajps.2014.519302
Altmetrics:http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.4236/ajps.2014.519302
ID Code:36953
Deposited By: Nabilah Mustapa
Deposited On:25 Jul 2015 11:43
Last Modified:21 Aug 2015 12:08

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